Lesions should be more sclerotic on xray/CT and should improve beyond 3months PSA level at which bone mets are uncommon 80% Small defect size in V/Q Means 25% and 35% Half life of I-131 8 days Energy of I-131 photon emission 364 keV Aluminum ion breakthrough limit 10microgram / mL Moly breakthrough limit. Distribution based on blood flow and osteoBLAST activity F18-PET vs Tc99m-MDP vs FDG-PET Tc99m-MDP looks blurry and shitty, F-18 looks great, high res, FDG-PET looks similar to F18 but with brain uptake Normal tracer uptake in Tc99m MDP Bones, kidneys (if very faint, superscan), bladder, breasts (esp young women), soft tissues (low), kids epiphyses Diffuse renal uptake on Tc-99m MDP Think chemotherapy High renal cortical uptake (higher than spine) on Tc99 MDP Think hemochromatosis Abnormally high skull suture uptake on Tc99m MDP Think renal osteodystrophy Causes of liver uptake on Tc99m MDP Al3+ contamination, cancer (hepatoma or mets), amyloid, liver necrosis MCC MDP hot lung met Osteosarcoma Chance a single MDP hot lesion is benign 80% Chance a single sternal lesion in breast cancer is benign on MDP 20% (Breast cancer 80%) Diffusely decreased skeletal uptake on MDP Free Tc, bisphosphonate therapy Flair phenomenon Lesions look worse on MDP scan 2 weeks to 3 months after tx. Mechanism of Tc99m MDP bone scan phosphonate binding to bone (chemisorption).
0 kommentar(er)
